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  2. Atorvastatin - Wikipedia

    en.wikipedia.org/wiki/Atorvastatin

    The first synthesis of atorvastatin at Parke-Davis that occurred during drug discovery was racemic followed by chiral chromatographic separation of the enantiomers. An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a ...

  3. Statin - Wikipedia

    en.wikipedia.org/wiki/Statin

    The exact mechanism responsible for the possible increased risk of diabetes mellitus associated with statin use is unclear. [105] However, recent findings have indicated the inhibition of HMGCoAR as a key mechanism. [109] Statins are thought to decrease cells' uptake of glucose from the bloodstream in response to the hormone insulin. [105]

  4. Discovery and development of statins - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Type 2 statins Statins that are fully synthetic and have larger groups linked to the HMG-like moiety are often referred to as type 2 statins. One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins. This group is responsible for ...

  5. Ezetimibe - Wikipedia

    en.wikipedia.org/wiki/Ezetimibe

    Ezetimibe, sold under the brand name Zetia among others, is a medication used to treat high blood cholesterol and certain other lipid abnormalities. [3] [4] Generally it is used together with dietary changes and a statin. [5]

  6. Simvastatin - Wikipedia

    en.wikipedia.org/wiki/Simvastatin

    A 2010 published meta-analysis found for every 255 patients taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. [27] Some drugs interact with statins in a way that increases the risk of muscle injury called myopathy, characterized by unexplained muscle weakness or pain.

  7. For Hubert Davis, it’s ‘Live Action’: Motivation behind the ...

    www.aol.com/hubert-davis-live-action-motivation...

    At times UNC coach Hubert Davis is a mild-mannered, arms-crossed observer on the sideline. At others he stomps, twirls, jumps. And now, once again, it’s Live Action.

  8. Rosuvastatin - Wikipedia

    en.wikipedia.org/wiki/Rosuvastatin

    Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins. [ 26 ] Putative beneficial effects of rosuvastatin therapy on chronic heart failure may be negated by increases in collagen turnover markers as well as a reduction in plasma coenzyme Q 10 levels in patients ...

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