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The region is conventionally divided into three divisions. CA3a is the part of the cell band that is most distant from the dentate (and closest to CA1). CA3b is the middle part of the band nearest to the fimbria and fornix connection. CA3c is nearest to the dentate, inserting into the hilus.
[26] [27] Commissural fibers that originate from CA3 Pyramidal cells go to CA3, CA2 and CA1 regions. Like mossy cells, a single CA3 Pyramidal cell contributes to both commissural and associational fibers, and they terminate on both principal cells and interneurons. [28] [29] A weak commissural projection connects both CA1 regions together ...
Place cell responses are shown by pyramidal cells in the hippocampus and by granule cells in the dentate gyrus. Other cells in smaller proportion are inhibitory interneurons, and these often show place-related variations in their firing rate that are much weaker. There is little, if any, spatial topography in the representation; in general ...
The dentate gyrus (DG) is part of the hippocampal formation in the temporal lobe of the brain, which also includes the hippocampus and the subiculum.The dentate gyrus is part of the hippocampal trisynaptic circuit and is thought to contribute to the formation of new episodic memories, [1] [2] the spontaneous exploration of novel environments [2] and other functions.
The temporal lobes are a region of the cerebral cortex that is located beneath the Sylvian fissure on both the left and right hemispheres of the brain. [14] Lobes in this cortex are more closely associated with memory and in particular autobiographical memory. [15] The temporal lobes are also concerned with recognition memory.
Most famous parts of the brain highlighted in different colours. The human brain anatomical regions are ordered following standard neuroanatomy hierarchies. Functional, connective, and developmental regions are listed in parentheses where appropriate.
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View of left entorhinal cortex (red) from beneath the brain, with front of brain at top. Artist's rendering. The superficial layers – layers II and III – of EC project to the dentate gyrus and hippocampus: Layer II projects primarily to dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 and the subiculum.