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  2. Muscle fatigue - Wikipedia

    en.wikipedia.org/wiki/Muscle_fatigue

    It was once believed that lactic acid build-up was the cause of muscle fatigue. [8] The assumption was lactic acid had a "pickling" effect on muscles, inhibiting their ability to contract. Though the impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.

  3. Lactic acidosis - Wikipedia

    en.wikipedia.org/wiki/Lactic_acidosis

    Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]

  4. Muscle weakness - Wikipedia

    en.wikipedia.org/wiki/Muscle_weakness

    It was once believed that lactic acid build-up was the cause of muscle fatigue. [14] The assumption was lactic acid had a "pickling" effect on muscles, inhibiting their ability to contract. The impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue. [citation needed]

  5. Exertional rhabdomyolysis - Wikipedia

    en.wikipedia.org/wiki/Exertional_rhabdomyolysis

    A loss of range of motion from swelling will also be seen in the affected limb. Along with muscle strength weakness associated with the muscles involved from loss of filament interaction. [15] Compartment syndrome in muscle. Dehydration is a common risk factor for exertional rhabdomyolysis because it causes a reduction of plasma volume during ...

  6. Adenosine monophosphate deaminase deficiency type 1

    en.wikipedia.org/wiki/Adenosine_monophosphate...

    If the load on muscles is greater than the body's ability to recycle lactate back into glucose, lactate will start to build up in the blood. Once lactate reaches its renal re-absorption threshold (5–6 mmol/L in general population), it gets lost to urine, wasting many calories (and producing bright matte yellow particles on surfaces where ...

  7. Cori cycle - Wikipedia

    en.wikipedia.org/wiki/Cori_cycle

    Cori cycle. The Cori cycle (also known as the lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, [1] is a metabolic pathway in which lactate, produced by anaerobic glycolysis in muscles, is transported to the liver and converted to glucose, which then returns to the muscles and is cyclically metabolized back to lactate.

  8. Mitochondrial toxicity - Wikipedia

    en.wikipedia.org/wiki/Mitochondrial_toxicity

    The most commonly observed symptom is muscle weakness, or myopathy. Others include peripheral neuropathy (numbness in the fingers and toes) and pancreatitis (inflammation of the pancreas), with the most severe being lactic acidosis , in which a build-up of lactic acid in the tissues of the body leads to loss of energy, organ failure, and ...

  9. Cellular waste product - Wikipedia

    en.wikipedia.org/wiki/Cellular_waste_product

    Lactic acid tends to accumulate in the muscles, which causes pain in the muscle and joint as well as fatigue. [13] It also creates a gradient which induces water to flow out of cells and increases blood pressure. [14] Research suggests that lactic acid may also play a role in lowering levels of potassium in the blood. [15]