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Taking metformin may cause unpleasant side effects like diarrhea, nausea, upset stomach and, in rare cases, lactic acidosis. Don’t double up on metformin if you miss a dose.
Common adverse effects include diarrhea, nausea, and abdominal pain. [16] It has a small risk of causing low blood sugar. [16] High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. [23] [24] Metformin is a biguanide anti-hyperglycemic agent. [16]
The most common side effects are gastrointestinal (everyone’s favs: diarrhea, bloating, stomach pain, gas, indigestion and constipation). These affect up to 30 percent of metformin users.
Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]
Image credits: Gilbert Flores/Variety/Getty Images Celebrity use and social media promotion of Ozempic have reportedly contributed to a shortage of the drug, which is intended to treat diabetes.
Medications to treat the toxic effects include: intravenous fluids, calcium gluconate, glucagon, high dose insulin, vasopressors and lipid emulsion. [1] [2] Extracorporeal membrane oxygenation may also be an option. [1] More than ten thousand cases of calcium channel blocker toxicity were reported in the United States in 2010. [2]
Diarrhea is a well-known side effect of metformin. Learn more about why this gut-related side effect happens and how to manage it. ... Learn more about why this gut-related side effect happens and ...
Drug overdose was the leading cause of injury death in 2013. Among people 25 to 64 years old, drug overdose caused more deaths than motor vehicle traffic crashes. There were 43,982 drug overdose deaths in the United States in 2013. Of these, 22,767 (51.8%) were related to prescription drugs. [33]
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