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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
By binding to μ-opioid receptors, loperamide inhibits acetylcholine release and decreases excitation of neurons in the myenteric plexus, which leads to a decrease in peristalsis. [4] Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating ...
These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). [ 2 ] Mechanisms of peripheral selectivity include physicochemical hydrophilicity and large molecular size, which prevent drug permeation through the lipid bilayer cell membranes of the blood–brain barrier, and efflux out of the brain by ...
As with any prescription medication, there are side effects of Wegovy to keep in mind. The most common side effects are gastrointestinal ones, like: Some foods may aggravate these side effects ...
A notable opioid for the purpose of relief of diarrhoea is loperamide which is only an agonist of the μ opioid receptors in the large intestine and does not have opioid affects in the central nervous system as it doesn't cross the blood–brain barrier in significant amounts. This enables loperamide to be used to the same benefit as other ...
"DirecTV has not yet reached an agreement with Disney. This means Disney-owned channels, including local ABC stations in 8 markets, ESPN, and other general entertainment and regional sports ...
If something is wrong with your mobile web browser, it can cause AOL websites to stop working. Get back to what you're doing by fixing the source of the problem. Try each step in order, then check to see if the issue is resolved before moving on. 1. Check if your device is connected to a network. 2. Update your browser to the latest version. 3.
It does not address the underlying cause (for example, infection or malabsorption), but it does decrease motility. Examples include diphenoxylate , loperamide , and eluxadoline . See also