Search results
Results from the WOW.Com Content Network
The diminished reactivity limits protein-carboplatin complexes, which are excreted. The lower excretion rate of carboplatin means that more is retained in the body, and hence its effects are longer lasting (a retention half-life of 30 hours for carboplatin, compared to 1.5-3.6 hours in the case of cisplatin).
Twice-daily dosing was not associated with increased toxicity. [3] In another phase I dose-escalation study, in 22 patients with advanced gynaecological malignancies, the maximum tolerated dose of BIBF 1120 twice-daily combined with paclitaxel and carboplatin was 200mg. [4]
Dose Mode Days Rituximab: 375 mg/m 2: IV infusion: Day 1 Ifosfamide: 5000 mg/m 2: IV continuous infusion over 24 hours: Day 2 Mesna for haemorrhagic cystitis prophylaxis with ifosfamide: 5000 mg/m 2: IV continuous infusion over 24 hours: Day 2 Carboplatin: Optimized to get AUC = 5 (max. 800 mg) IV infusion: Day 2 Etoposide: 100 mg/m 2: IV ...
In conventional chemotherapy, a dose close to the maximum tolerated dose is administered in a bolus manner to achieve cytotoxic effects on tumor cells. [5] However, the side effects are often significant as the cytotoxic agents also kill the fast-dividing cells normally present in the body, such as bone marrow cells and epithelial cells of the gastrointestinal tract. [6]
Absolute bioavailability refers to the bioavailability of a drug when administered via an extravascular dosage form (i.e. oral tablet, suppository, subcutaneous, etc.) compared with the bioavailability of the same drug administered intravenously (IV). This is done by comparing the AUC of the non-intravenous dosage form with the AUC for the drug ...
Oncologists are already individualizing dosing of some cancer drugs based on exposure. Carboplatin [29]: 4 and busulfan [30] [31] dosing rely upon results from blood tests to calculate the optimal dose for each person. Simple blood tests are also available for dose optimization of methotrexate, [32] 5-FU, paclitaxel, and docetaxel. [33] [34]
High-dose chemotherapy using cyclophosphamide, cisplatin, and carmustine with hematologic stem-cell support or marrow support on patients aged 60 years or younger who had achieved complete or partial remission with conventional induction chemotherapy also showed significant increase in five-year survival rate to 41% - 53%.
C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.