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Proteins from the TGF-beta superfamily are only active as homo- or heterodimer; the two chains being linked by a single disulfide bond. From X-ray studies of TGF-beta-2, [7] it is known that all the other cysteines are involved in intrachain disulfide bonds. As shown in the following schematic representation, there are four disulfide bonds in ...
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.
The TGF beta ligand binds to a type II receptor dimer, which recruits a type I receptor dimer forming a hetero-tetrameric complex with the ligand. [6] These receptors are serine/threonine kinase receptors. They have a cysteine rich extracellular domain, a transmembrane domain, and a cytoplasmic serine/threonine rich domain.
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene. [5] [6]
Transforming growth factor beta (TGF-β) is a potent cell regulatory polypeptide homodimer of 25kD. [1] It is a multifunctional signaling molecule with more than 40 related family members. TGF-β plays a role in a wide array of cellular processes including early embryonic development, cell growth, differentiation, motility, and apoptosis.
The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions. TGFβ is a growth factor and cytokine involved in paracrine signalling and can be found in many different tissue types, including brain , heart , kidney ...
21808 Ensembl ENSG00000092969 ENSMUSG00000039239 UniProt P61812 P27090 RefSeq (mRNA) NM_003238 NM_001135599 NM_009367 NM_001329107 RefSeq (protein) NP_001129071 NP_003229 NP_001316036 NP_033393 Location (UCSC) Chr 1: 218.35 – 218.44 Mb Chr 1: 186.35 – 186.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as ...
Transforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms .