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Quinoline is mainly used as in the production of other specialty chemicals. Approximately 4 tonnes were produced annually according to a report published in 2005. [ 8 ] Its principal use is as a precursor to 8-hydroxyquinoline , which is a versatile chelating agent and precursor to pesticides.
Alkaloids with a quinoline partial structure are widespread and are usually further subdivided according to their occurrence and biogenetic origin. Among the quinoline alkaloids are the cinchona alkaloids quinine and quinidine , which are important due to their therapeutic potential, furthermore cinchonine and cinchonidine, as well as some ...
It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in many naturally occurring alkaloids such as ...
The majority of quinolones in clinical use belong to the second generation class of "fluoroquinolones", which have a true quinoline framework, maintain the C-3 carboxylic acid group, and add a fluorine atom to the all-carbon containing ring, typically at the C-6 or C-8 positions. [73]
The isoquinoline alkaloids are primarily formed in the plant families of Papaveraceae, Berberidaceae, Menispermaceae, Fumariaceae and Ranunculaceae.. The opium poppy, which belongs to the Papavaraceae family, is of great interest, since the isoquinoline alkaloids morphine, codeine, papaverine, noscapine and thebaine can be found in its latex. [3]
Quinine is a medication used to treat malaria and babesiosis. [5] This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. [5] [6] While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. [5]
Medicinal tonic water originally contained only carbonated water and a large amount of quinine. Most modern tonic waters contain comparatively less quinine, and are often enhanced by citrus flavors. As a result of the lower quinine content, tonic water is less bitter.
4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline. The compound has been used as a precursor for the synthesis of its derivatives. [1] A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. [2]