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The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C
A.—Diagram of the primitive urogenital organs, from 'Diagrams to show the development of male and female generative organs from a common type' * w, w. Right and left Wolffian ducts. The observable, visual differences become apparent between male or the female reproductive organs are not seen initially.
B.—Diagram of the female type of sexual organs. C. Greater vestibular gland, and immediately above it the urethra. cc. Corpus cavernosum clitoridis. dG. Remains of the left Wolffian duct, such as give rise to the duct of Gärtner, represented by dotted lines; that of the right side is marked w. f. The abdominal opening of the left uterine ...
B.—Diagram of the female type of sexual organs. C. Greater vestibular gland, and immediately above it the urethra. cc. Corpus cavernosum clitoridis. dG. Remains of the left Wolffian duct, such as give rise to the duct of Gärtner, represented by dotted lines; that of the right side is marked w. f. The abdominal opening of the left uterine ...
The mesonephric duct, also known as the Wolffian duct, archinephric duct, Leydig's duct or nephric duct, is a paired organ that develops in the early stages of embryonic development in humans and other mammals. It is an important structure that plays a critical role in the formation of male reproductive organs.
The mesonephric system is the precursor to the male genitalia and the paramesonephric to the female reproductive system. [8] As development proceeds, one of the pairs of ducts develops while the other regresses. This depends on the presence or absence of the sex determining region of the Y chromosome, also known as the SRY gene. [5]
Androgens are synthesized in the testes, the ovaries, and the adrenal glands. Androgens increase in both males and females during puberty. [3] The major androgen in males is testosterone. [4] Dihydrotestosterone (DHT) and androstenedione are of equal importance in male development. [4] DHT in utero causes differentiation of the penis, scrotum ...
Sertoli cells function to nourish the developing sperm cells. They secrete androgen-binding protein, a binding protein which increases the concentration of testosterone. There are two types: convoluted and straight, convoluted toward the lateral side, and straight as the tubule comes medially to form ducts that will exit the testis.