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Aminoacylase Reaction Mechanism (click for larger image) Aminoacylase is a metallo-enzyme that needs Zinc (Zn 2+) as a cofactor to function. [3] [4] The Zinc ions inside of aminoacylase are each coordinated to histidine, glutamate, aspartate, and water. [1] [3] [5] The Zinc ion polarizes the water, facilitating its deprotonation by a nearby ...
Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids.
Aminoacylase 1 (ACY1: EC 3.5.14) is a zinc binding enzyme which hydrolyzes N-acetyl amino acids into the free amino acid and acetic acid. Of the N-acetyl amino hydrolyzing enzymes, aminoacylase 1 is the most common. [citation needed] The ACY1 gene is located on the short arm of chromosome 3 (3p21.2). [citation needed]
Aspartoacylase is a hydrolytic enzyme (EC 3.5.1.15, also called aminoacylase II, ASPA and other names [a]) that in humans is encoded by the ASPA gene. ASPA catalyzes the deacylation of N -acetyl-l-aspartate ( N-acetylaspartate) into aspartate and acetate .
Canavan disease, or Canavan–Van Bogaert–Bertrand disease, is a rare and fatal autosomal recessive [1] degenerative disease that causes progressive damage to nerve cells and loss of white matter in the brain. [2]
235606 Ensembl ENSG00000164062 ENSMUSG00000032590 UniProt P13798 Q8R146 RefSeq (mRNA) NM_001640 NM_146226 RefSeq (protein) NP_001631 NP_666338 Location (UCSC) Chr 3: 49.67 – 49.68 Mb Chr 9: 107.96 – 107.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Acylamino-acid-releasing enzyme is an enzyme that in humans is encoded by the APEH gene. This gene encodes the enzyme ...
Other names in common use include long-chain aminoacylase, long-chain-fatty-acyl-glutamate deacylase, long-chain acylglutamate amidase, and N-acyl-D-glutamate deacylase. References [ edit ]
In enzymology, a N-acyl-D-amino-acid deacylase (EC 3.5.1.81) is an enzyme that catalyzes the chemical reaction. N-acyl-D-amino acid + H 2 O an acid + D-amino acid. Thus, the two substrates of this enzyme are N-acyl-D-amino acid and H 2 O, whereas its two products are acid and D-amino acid.