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V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. [1] [2] It is a driver mutation in a proportion of certain diagnoses, including melanoma, [3] [4] hairy cell leukemia, [5] [6] papillary thyroid carcinoma, [7] [8] colorectal cancer, [9] non-small-cell lung cancer, [10] [11] Langerhans cell histiocytosis, [12] Erdheim–Chester ...
Exercise-induced collapse (EIC) is a genetic disorder, mainly found in Labrador Retrievers, [1] Chesapeake Bay Retrievers , Curly Coated Retrievers, and Boykin Spaniels. . The genetic mutation has also been seen in a few cases in Cocker spaniels, German wire-haired pointers, Old English Sheepdogs, Bouvier des Flandres, Pembroke Welsh Corgis and Clumber Spani
BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B , while the protein is more formally known as serine/threonine-protein kinase B-Raf .
For a blood transfusion to take place, the donor and recipient must be of compatible blood types. Dogs have eleven blood types but are born without antibodies in their blood. For this reason, first time transfusions will not have a reaction, but further transfusions will cause severe reactions if the dog has a mismatch in the DEA1.1 blood type ...
Dogs that are DEA 1.1 negative are universal donors. Blood from DEA 1.1 positive dogs should never be transfused into DEA 1.1 negative dogs. If it is the dog's first transfusion the red cells transfused will have a shortened life due to the formation of alloantibodies to the cells themselves and the animal will forever be sensitized to DEA 1.1 ...
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The experiments start with a dog's heart, attached to a set of tubes to serve as substitutes for the great vessels. Using a system to supply it with blood, the heart beats in the same manner as if it were inside a living organism. The film then shows a lung in a tray, which is operated by bellows that oxygenate the blood being sent to the heart.
A scanning electron micrograph depicted a number of Gram-negative Bordetella bronchiseptica bacteria. In veterinary medicine, B. bronchiseptica leads to a range of pathologies in different hosts. It is a serious disease of dogs, pigs, and rabbits, and has been seen in cats, horses, and seals. A PCR test for the pathogen exists. [8]