Search results
Results from the WOW.Com Content Network
Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
[1] [2] [7] For comparison, the affinities of LSD and DOM in the same study were 6.31 nM and 18.6 nM, respectively. [7] DOSB substitutes for LSD in rodent drug discrimination tests, albeit much less potently than DOM ( ED 50 Tooltip median effective dose = 1.80 mg/kg versus 0.148 mg/kg, respectively; ~12-fold difference) and with only partial ...
[1] [2] The EC 50 Tooltip half-maximal effective concentration values for induction of monoamine release in rat brain synaptosomes have been reported for the individual enantiomers of 6-MBPB. [2] In the case of ( S )-6-MBPB, they were 54 nM for serotonin , 77 nM for norepinephrine , and 41 nM for dopamine , whereas for ( R )-6-MBPB, they were ...
2C-iBu is a highly potent and robustly efficacious serotonin 5-HT 2A receptor agonist. [4] Its EC 50 Tooltip half-maximal effective concentration values are 1.3 nM for calcium mobilization and 57.5 nM for β-arrestin-2 recruitment, whereas its E max Tooltip maximal efficacy values are 103% for calcium mobilization and 77% for β-arrestin-2 recruitment relative to serotonin. [4]
Main page; Contents; Current events; Random article; About Wikipedia; Contact us; Help; Learn to edit; Community portal; Recent changes; Upload file
VU0530244 is a potent, selective, and putatively peripherally restricted serotonin 5-HT 2B receptor antagonist which was first described in 2023. [1] [2] [3] Another similar drug, VU0631019, was also described alongside VU0530244. [3]
Conversely, BMB-A39a shows minimal or negligible activity in activating the serotonin 5-HT 2B receptor (E max < 20%) and does not activate other serotonin receptors. [ 3 ] [ 4 ] BMB-201 is said to have minimal or absent psychedelic effects due to its reduced serotonin 5-HT 2A receptor intrinsic activity but to potently induce neuroplasticity .