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Cushing's is an umbrella term for conditions caused by elevated cortisol and adrenocorticotropic hormone levels. Cushing's disease most commonly refers to pituitary-dependent hyperadrenocorticism, the most common condition of Cushing's syndrome, but 'Cushing's' is used to refer to all hyperadrenocorticism conditions. [2]
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Cushing syndrome can be hard to diagnose. Here's what it is, as well as what causes it and how it's treated.
Although any age, breed, or sex of cat can develop feline hyperesthesia syndrome, it has been noted that Abyssinian, Burmese, Himalayan and Siamese breeds appear to have an increased risk of developing the disease, therefore there is the possibility of a genetic link. [1] [3] [4] [11]
Genetics may play a part in the risk factor. [2] Certain cat breeds may have a predisposition. [4] Dogs suffering from diabetes mellitus, Cushing's disease (hyperadrenocorticism), hypothyroidism, and epilepsy have been reported to have an increased risk but no there is a lack of evidence to support a link between the conditions and pancreatitis ...
It’s been documented in domestic cats in Europe since the 1970s, and has also been found in rodents. A similar syndrome was reported in Alabama cats 45 years ago, but the cause was obscure.
PPNAD, the endocrine manifestation that comes from Carney Complex (CNC), can be syndromic or isolated. The main cause of isolated PPNAD is a mutation of PRKAR1α, located at 17q22-24, which is the gene encoding the regulatory R1α subunit of protein kinase A. Germline heterozygous PRKAR1α inactivation mutations are present in 80% of CNC patients affected by Cushing's syndrome. [8]