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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
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It might be helpful for people new to Lipinski's rule to have a description of "Clog" on the page. It is an unusual and somewhat confusing notation. Could someone please add this information? 6.626X10^-34 16:45, 26 September 2024 (UTC)
The episode (Season 2, Episode 2) includes one of the few occasions Cambot actually interacts in a way other than filming the experiment, by placing an ESPN-like score graphic during the movie's racing scenes. [1] The episode was released on DVD by Rhino Entertainment as part of the third volume of Mystery Science Theater 3000 DVD box sets.
Georgia Rule is a 2007 American black comedy-drama film directed by Garry Marshall from a screenplay by Mark Andrus.Starring Jane Fonda, Lindsay Lohan and Felicity Huffman, the film follows a rebellious young woman (Lohan) who is sent to spend the summer with her grandmother (Fonda) when her frustrated mother (Huffman) can't control her unruly behavior.
According to Robert Osborne of Turner Classic Movies, the film is the first to depict the aftermath of an Earthly atomic bomb catastrophe.. The unusual house that is the setting for most of the film was designed by Frank Lloyd Wright and was the separate guesthouse of the ranch of producer/director/writer Arch Oboler, [5] located at 32436 Mulholland Highway in Malibu, California. [6]
Rule no. 5 - Praise him for almost everything, so he is comfortable in saying 'I love you' She follows all these rules and finally makes him fall in love with her. But then she realizes that she does not love him and that she forced him into loving her by following the rules. She feels very bad about what she has done, and breaks up with him.