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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five, which covers the numbers of hydrophilic groups, molecular weight and hydrophobicity. Since the drug is transported in aqueous media like blood and intracellular fluid, it has to be sufficiently water-soluble in the absolute sense (i.e. must have a ...
Lipinski, 41, told TODAY contributing correspondent Kaylee Hartung. “Todd and I have a baby girl, Georgie Winter, that arrived into our arms by the most beautiful surrogate.”
Psychologists Arthur and Elaine Aron are known for research behind the “36 Questions That Lead to Love.” They share how their relationship has lasted over 50 years.
However, the Druglikeness article is sufficiently minute that having a section devoted to Lipinski's rule that encompasses the entire current article content is not unfeasible or unreasonable. To the matter of being able to find the information, that is solved by retaining a redirect ... that will show up both in searches and when formulating a ...
Weir and Lipinski discussed the incident as a moment of silence was held before the pairs final, which took place in Tallinn, Estonia. "As we come on the air for the European Figure Skating ...
Pages in category "Rules of thumb" The following 63 pages are in this category, out of 63 total. ... Lipinski's rule of five; Looney 11 rule; M. Markovnikov's rule ...