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Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs. [1] It acts against interleukin 31 (IL-31), [2] which is a cytokine involved in causing itchiness (pruritus). [2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks. [3]
Cytopoint [90] mab: veterinary: Canis lupus familiaris IL31: Y: clinical signs of atopic dermatitis in dogs [90] Lorvotuzumab mertansine: mab: humanized: CD56: cancer Lucatumumab [13] mab: human: CD40: multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma: Lulizumab pegol [6] mab: humanized: CD28: autoimmune diseases Lumiliximab [9] mab ...
Seviteronel (developmental codes VT-464 and, formerly, INO-464) is an experimental cancer medication which is under development by Viamet Pharmaceuticals and Innocrin Pharmaceuticals for the treatment of prostate cancer and breast cancer. [1]
Created Date: 8/30/2012 4:52:52 PM
A world literature review and mid-cycle literature update were provided. This produced over 600 references. These references were reviewed by both the sponsor and Drs. Cai and Dubitsky who felt that they did not reveal any previously unreported serious adverse events likely to be causally associated with risperidone. 7.0 Foreign Regulatory Action
Mild joint involvement can be effectively treated with NSAIDs, hydroxychloroquine, and oral prednisone. [ 71 ] [ 44 ] [ 25 ] Methotrexate has been observed to be useful in more severe cases. [ 72 ] If methotrexate is contraindicated, alternative disease-modifying medications for RA, such as leflunomide or azathioprine , may be used. [ 68 ]
In general, use a potent preparation short term and weaker preparation for maintenance between flare-ups. While there is no proven best benefit-to-risk ratio, [11] if prolonged use of a topical steroid on a skin surface is required, a pulse therapy should be undertaken.
Deflazacort's potency is around 70–90% that of prednisone. [8] A 2017 review found its activity of 7.5 mg of deflazacort is approximately equivalent to 25 mg cortisone , 20 mg hydrocortisone , 5 mg of prednisolone or prednisone , 4 mg of methylprednisolone or triamcinolone , or 0.75 mg of betamethasone or dexamethasone .