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Analysis of their adipose tissue morphology revealed increases in both adipocyte size and number in most depots. Reintroduction of an ordinary chow diet [13] to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. Adipocyte number remained at the elevated level achieved during the period of ...
Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. [1] [2] It also contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages.
In contrast to white adipocytes, which contain a single lipid droplet, brown adipocytes contain numerous smaller droplets and a much higher number of (iron-containing) mitochondria, which gives the tissue its color. [3] Brown fat also contains more capillaries than white fat. These supply the tissue with oxygen and nutrients and distribute the ...
The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue.Some contribute to an obesity-related low-grade state of inflammation or to the development of metabolic syndrome, a constellation of diseases including, but not limited to, type 2 diabetes, cardiovascular disease and atherosclerosis. [1]
Adipose tissue is an endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. [1] These hormones generally influence energy metabolism, which is of great interest to the understanding and treatment of type 2 diabetes and obesity.
White adipose tissue is composed of monolocular adipocytes. In humans, the healthy amount of white adipose tissue varies with age, but composes between 6–25% of body weight in adult men and 14–35% in adult women.
They can be readily distinguished by their expression of TIM4 and MHC class II markers in mice. It was shown that TIM4+ MHCII- macrophages originate in the embryo, even before adipocytes are fully formed, while TIM4- MHCII+ arise in the bone marrow. [6] The formation of ATM identity critically depends on the transcription factor c-Maf. [6]
Histology features of a lipoblast, also known as an adipocyte precursor cell or preadipocyte.. Adipogenesis is the formation of adipocytes (fat cells) from stem cells. [1] It involves 2 phases, determination, and terminal differentiation.