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Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents. It is used to describe the phenomenon underlying discrimination of self from non-self, suppressing allergic responses, allowing chronic infection instead of rejection and elimination, and preventing ...
Tolerogenic therapy aims to induce immune tolerance where there is pathological or undesirable activation of the normal immune response.This can occur, for example, when an allogeneic transplantation patient develops an immune reaction to donor antigens, or when the body responds inappropriately to self antigens implicated in autoimmune diseases. [1]
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Vitamin D is known as an immune regulator that assists in the adaptive and innate immune response. [ 86 ] [ 87 ] A deficiency in vitamin D, from hereditary or environmental influence, can lead to a more inefficient and weaker immune response and seen as a contributing factor to the development of autoimmune diseases. [ 87 ]
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The first major immunologic model was the Self/Non-self Model proposed by Macfarlane Burnet and Frank Fenner in 1949 with later refinement by Burnet. [1] [2] It theorizes that the immune system distinguishes between self, which is tolerated, and non-self, which is attacked and destroyed.
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