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A mouse-human hybrid is a genetically modified mouse whose genome has both mouse and human genes, thus being a murine form of a human-animal hybrid. For example, genetically modified mice may be born with human leukocyte antigen genes in order to provide a more realistic environment when introducing human white blood cells into them in order to ...
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. [ 5 ] [ 6 ] Mdm2 is an important negative regulator of the p53 tumor suppressor.
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene ...
The gene targeting method in knockout mice uses mouse embryonic stem cells to deliver artificial genetic material (mostly of therapeutic interest), which represses the target gene of the mouse by the principle of homologous recombination. The mouse thereby acts as a working model to understand the effects of a specific mammalian gene.
20464 Ensembl ENSG00000112246 ENSMUSG00000019913 UniProt P81133 Q61045 RefSeq (mRNA) NM_005068 NM_001374769 NM_011376 RefSeq (protein) NP_005059 NP_001361698 NP_035506 Location (UCSC) Chr 6: 100.39 – 100.46 Mb Chr 10: 50.77 – 50.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Single-minded homolog 1, also known as class E basic helix-loop-helix protein 14 (bHLHe14), is a ...
Both human and mouse motifs are largely clustered in the 200 bp [Figure 2], the known 3′ enhancers in the TCR/ were identified, and a conserved region of 100 bp in the mouse J intron was subsequently shown to have a regulatory function. [Figure 2] Gene structure of the human (top) and mouse (bottom) V, D, J, and C gene segments.
Colors in the human chromosomes indicate regions homologous with parts of the mouse chromosome of the same color. For instance, sequences homologous to mouse chromosome 1 are primarily on human chromosomes 1 and 2, but also 6, 8, and 18. The X chromosome is almost completely syntenic in both species. [1] In genetics, the term synteny refers to ...
The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [4]