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  2. Madin-Darby canine kidney cells - Wikipedia

    en.wikipedia.org/.../Madin-Darby_Canine_Kidney_Cells

    Epithelial cells in culture grow normally as tight clusters. However, they could be induced to break cell-cell contacts and become elongated and motile after exposure to a "scatter factor" that was secreted by mesenchymal cells such as Swiss 3T3 fibroblasts. [12] This was best described by Julia Gray's group in 1987. [13]

  3. Cluster of differentiation - Wikipedia

    en.wikipedia.org/wiki/Cluster_of_differentiation

    The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).

  4. T-cell depletion - Wikipedia

    en.wikipedia.org/wiki/T-cell_depletion

    Antiretroviral therapy, the most common treatment for patients with HIV, has been shown to restore CD4+ T cell counts. [20] The body responds to T cell depletion by producing an equal amount of T cells. However, over time, an individual's immune system can no longer continue to replace CD4+ T cells. [21] This is called the "tap and drain ...

  5. Histiocytoma (dog) - Wikipedia

    en.wikipedia.org/wiki/Histiocytoma_(dog)

    Canine histiocytoma cytology. A histiocytoma originates from epidermal Langerhans cells of antigen-presenting cell lineage. [4] Spontaneous regression is common in these tumors, and it is mediated by infiltration of CD8-expressing T cells followed by expression of Type 1 T helper cell cytokines (such as Interferon-gamma) and recruitment of antitumour effector cells.

  6. Cellular differentiation - Wikipedia

    en.wikipedia.org/wiki/Cellular_differentiation

    During terminal differentiation, a precursor cell formerly capable of cell division permanently leaves the cell cycle, dismantles the cell cycle machinery and often expresses a range of genes characteristic of the cell's final function (e.g. myosin and actin for a muscle cell). Differentiation may continue to occur after terminal ...

  7. T helper 17 cell - Wikipedia

    en.wikipedia.org/wiki/T_helper_17_cell

    T helper 17 cells (T h 17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that cause T h 17s to actually inhibit T reg differentiation. [1] However, T h 17s are developmentally distinct from T h 1 and T h 2 lineages.

  8. T helper cell - Wikipedia

    en.wikipedia.org/wiki/T_helper_cell

    IL-4 is the positive feedback cytokine for T h 2 cells differentiation. Besides, IL-4 stimulates B-cells to produce IgE antibodies, which in turn stimulate mast cells to release histamine, serotonin, and leukotriene to cause broncho-constriction, intestinal peristalsis, gastric fluid acidification to expel helminths. IL-5 from CD4 T cells will ...

  9. Immunosuppressive drug - Wikipedia

    en.wikipedia.org/wiki/Immunosuppressive_drug

    Muromonab-CD3 is a murine anti-CD3 monoclonal antibody of the IgG2a type that was previously used to prevent T-cell activation and proliferation by binding the T-cell receptor complex present on all differentiated T cells. As such it was one of the first potent immunosuppressive substances and was administered to control the steroid- and/or ...