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Valerian has been used in herbal medicine for insomnia and conditions associated with anxiety; however, there is no good evidence that it is effective for these purposes. [ 3 ] [ 4 ] The chemical is 3-methylbutyric acid, also known as isovaleric acid or isopentanoic acid.
Valerian (V. officinalis) essential oil. Although valerian is a common traditional medicine used for treating insomnia, there is no good evidence it is effective for this purpose. [3] [5] [21] Valerian has not been shown to be helpful in treating restless leg syndrome [22] or anxiety. [23]
Valerian: garden valerian, garden heliotrope, all-heal Valeriana officinalis "drowsiness, GI upset, headache, palpitations, insomnia", [3] oversedation, overstimulation [16] Vasambu sweet flag Acorus calamus: Vomiting and nausea [22] Yohimbe: yohimbine Pausinystalia johimbe: rapid heart rate, hypertension, hypotension, heart problems, death [4]
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Valerenic acid may be at least partly responsible for valerian's sedative effects, in addition to the other valerenic acids hydroxyvalerenic acid and acetoxyvalerenic acid. [3] [1] Valerian supplements are often standardized to contain a particular amount of valerenic acid by weight (often 0.8%). [3]
The Indian Valerian has long been used in Ayurveda (Charak Samhita and Susruta) and Unani systems of medicine, which describe its use in obesity, skin disease, insanity, epilepsy and snake poisoning. The crude drugs from roots/ rhizomes and Valerian derived phytomedicines are used as mild sedatives in pharmaceutical industry.