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The 4Kscore combines total, free, and intact PSA with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
Medicare typically covers annual preventive care, including the PSA test, if you meet the eligibility criteria. Learn more.
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Prostate biopsy is a procedure in which small hollow needle-core samples are removed from a man's prostate gland to be examined for the presence of prostate cancer.It is typically performed when the result from a PSA blood test is high. [1]
Prostate-specific antigen testing is routinely used as the first step in the UK to investigate men with urinary symptoms.
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Since signs of asymptomatic prostatic inflammation may sometimes be associated with prostate cancer, this can be addressed by tests that assess the ratio of free-to-total PSA. The results of these tests were significantly different in prostate cancer and category IV prostatitis in one study. [6]
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