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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
Subsequently, the National Academy of Sciences (NAS) reviewed the health implications of perchlorate, and in 2005 proposed a much higher alternative reference dose of 0.0007 mg/kg/day based primarily on a 2002 study by Greer et al. [6] During that study, 37 adult human subjects were split into four exposure groups exposed to 0.007 (7 subjects ...
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit, on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation.
An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...
The Broselow Tape is designed for children up to approximately 12 years of age who have a maximum weight of roughly 36 kg (79 lb). The Broselow Tape is recognized in most medical textbooks and publications as a standard for the emergency treatment of children. [2]
The estimations in the above tables are based weight and height data from the U.S. NCHS National Health and Nutrition Examination Survey (2011-2014). [ 18 ] There was an average BSA of 1.73 m 2 for 3,000 cancer patients from 1990 to 1998 in a European Organisation for Research and Treatment of Cancer (EORTC) database.
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The Estimated Energy Requirement, , is the estimated number of daily kilocalories, or Calories, an individual requires in order to maintain his or her current weight.For a person with a body mass of (kg), height of (m), age of (years) and Physical Activity , this is given by