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The average dose necessary for effective antitussive therapy is between 10 and 45 mg, depending on the individual. The International Society for the Study of Cough recommends "an adequate first dose of medication is 60 mg in the adult and repeat dosing should be infrequent rather than qds recommended." [39]
In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17]
In Study 1 (GEMINI), a 6-week randomized controlled trial of dextromethorphan/bupropion versus placebo in people with major depressive disorder, scores on the Montgomery–Åsberg Depression Rating Scale (MADRS)—a scale with a range of 0 to 60 points—decreased with dextromethorphan/bupropion by 15.9 points from a baseline score of 33.6 ...
Some cough medicines may be no more effective than placebos for acute coughs in adults, including coughs related to upper respiratory tract infections. [7] The American College of Chest Physicians emphasizes that cough medicines are not designed to treat whooping cough , a cough that is caused by bacteria and can last for months. [ 8 ]
A person is prohibited to purchase more than 3.6 grams of dextromethorphan containing products within a 30-day period unless it is in pursuant to a valid prescription. Any person found in violation of this bill is guilty of a misdemeanor and subject to a fine of $1000, or imprisonment of not more than one year, or both the fine and the ...
Dosage forms (also called unit doses) are pharmaceutical drug products presented in a specific form for use. They contain a mixture of active ingredients and inactive components ( excipients ), configured in a particular way (such as a capsule shell) and apportioned into a specific dose .
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. ...
Side effects may include dizziness, sleepiness, skin rash, and nausea. [4] While it has not been properly studied in pregnancy, it appears to be safe. [7] It has been alleged to work in 2023 [4] by making airway secretions more liquid, even as it has been demonstrated not to work. [5] [6] Guaifenesin has been used medically since at least 1933. [8]
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