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The end-bulbs of Krause were thought to be thermoreceptors, sensing cold temperatures, but in early research their function remained unknown. [3] Recently optogenetic studies revealed their role in sexual stimulation and mating behavior in mice:
Krause discovered and described mechanoreceptors that were to become known as "Krause's corpuscles", sometimes referred to as "Krause's end-bulbs". [citation needed] His name is also associated with: "Krause's membranes": defined as isotropic bands in striated muscle fiber that consist of disks of sarcoplasm and connect the individual fibrils ...
This spindle-shaped receptor is sensitive to skin stretch, and contributes to the kinesthetic sense of and control of finger position and movement. [3] They are at the highest density around the fingernails where they act in monitoring slippage of objects along the surface of the skin, allowing modulation of grip on an object.
The end-bulb of Krause or bulboid corpuscle detects temperatures above body temperature. Ruffini's end organ detects temperatures below body temperature. TRPV1 is a heat-activated channel that acts as a small heat detecting thermometer in the membrane which begins the polarization of the neural fiber when exposed to changes in temperature.
The middle fibers are supposed by Krause to assist in the erection of the corpus spongiosum, by compressing the erectile tissue of the bulb. The anterior fibers also contribute to the erection of the penis by compressing the deep dorsal vein of the penis as they are inserted into, and continuous with, the fascia of the penis.
Merkel nerve endings have a widely distributed in glabrous and hairy skin, in hair follicles, and in oral and anal mucosa. [citation needed]Meckel nerve endings are most numerous beneath the ridges of the fingertips which make up fingerprints, and less so in the palms and forearm.
In male human anatomy, the glans penis or penile glans, [1] commonly referred to as the glans, (/ ɡ l æ n z /; from Latin glans meaning "acorn") [2] is the bulbous structure at the distal end of the human penis that is the human male's most sensitive erogenous zone and primary anatomical source of sexual pleasure.
[3] 20 to 40 glands of Krause are found in the upper fornix, and 6-8 glands appear in the lower fornix. [4] There are usually 2 to 5 Ciaccio's glands, and are found along the superior tarsal border of the upper eyelid. [1] Popov’s glands are located within the substance of the caruncle. [1]