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Epithelial polarity is one example of the cell polarity that is a fundamental feature of many types of cells. Epithelial cells feature distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the ...
Epithelial cells also exhibit planar cell polarity, in which specialized structures are orientated within the plane of the epithelial sheet. Some examples of planar cell polarity include the scales of fish being oriented in the same direction and similarly the feathers of birds, the fur of mammals, and the cuticular projections (sensory hairs ...
More recently, through loss-of-function and rescue-phenotype studies, RANKL is shown to be a receptor activator of NF-κB ligand and play a role in differentiation of M cells. RANKL is expressed throughout the small intestine, facilitates uptake of pathogens such as Salmonella, and is the most critical factor M cell differentiation. [ 5 ]
Bacterial microcompartments are widespread, organelle-like structures that are made of a protein shell that surrounds and encloses various enzymes. provide a further level of organization; they are compartments within bacteria that are surrounded by polyhedral protein shells, rather than by lipid membranes. These "polyhedral organelles ...
Cell junctions [1] or junctional complexes are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. [2] They also maintain the paracellular barrier of epithelia and control paracellular transport. Cell junctions ...
The glycocalyx (pl.: glycocalyces or glycocalyxes), also known as the pericellular matrix and cell coat, is a layer of glycoproteins and glycolipids which surround the cell membranes of bacteria, epithelial cells, and other cells. [1] Animal epithelial cells have a fuzz-like coating on the external surface of their plasma membranes.
Prevent the free diffusion of water and solutes among adjacent epithelial cells. [2] [13] Preserve the epithelial polarity and cell adhesion. [2] Have a function in the morphogenesis like tracheal morphology that regulate the cell size and the cell length. [14] Regulate cell proliferation. [14]
Planar cell polarity (PCP) is the protein-mediated signaling that coordinates the orientation of cells in a layer of epithelial tissue. In vertebrates, examples of mature PCP oriented tissue are the stereo-cilia bundles in the inner ear, [ 1 ] motile cilia of the epithelium, [ 2 ] and cell motility in epidermal wound healing. [ 3 ]