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The end-bulbs of Krause were thought to be thermoreceptors, sensing cold temperatures, but in early research their function remained unknown. [3] Recently optogenetic studies revealed their role in sexual stimulation and mating behavior in mice:
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The end-bulb of Krause or bulboid corpuscle detects temperatures above body temperature. Ruffini's end organ detects temperatures below body temperature. TRPV1 is a heat-activated channel that acts as a small heat detecting thermometer in the membrane which begins the polarization of the neural fiber when exposed to changes in temperature.
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Johann Friedrich Wilhelm Krause (12 July 1833 – 4 February 1910) was a German anatomist born in Hanover. He was the son of anatomist Karl Friedrich Theodor Krause (1797-1868). Krause studied at Göttingen , where he became member of the Burschenschaft Hannovera (fraternity).
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