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When heated under conditions of 110 °C, decarboxylation generally occurs in 30–45 minutes. The decarboxylated THCA (THC) is added to cannabis edibles, as THCA is not orally active. When consumed orally, the liver breaks down and metabolizes THC into the more potent 11-hydroxy-THC.
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Cannabis is the most widely used illicit drug in the Western world. [3] In the United States, 10-20% of those who begin the use of cannabis daily will later become dependent. [4] [5] Cannabis use can lead to addiction, which is defined as "when the person cannot stop using the drug even though it interferes with many aspects of his or her life."
Next, 11-OH-THC is metabolized in the liver into 11-COOH-THC, which is the second metabolic product of THC. [66] 11-COOH-THC is not psychoactive. [64] Ingestion of edible cannabis products lead to a slower onset of effect than the inhalation of it because the THC travels to the liver first through the blood before it travels to the rest of the ...
We know that THC is an anti-inflammatory and can help with pain (hence the reason for medicinal marijuana and why CBD as a skincare ingredient was so popular years ago).
A 2022 study published in the Journal of Psychopharmacology found that participants given oral cannabis (the lab-grade alternative to an edible) showed low blood THC concentration at the height of ...
Cannabis can also be consumed as a cannabis tea and many other beverages. Although THC is lipophilic and only slightly water soluble (with a solubility of 2.8 mg per liter), [13] enough THC can be dissolved to make a mildly psychoactive tea. However, water-based infusions (liquid edibles) are generally considered to be an inefficient use of the ...
Compared to the immediate high of smoking cannabis, the high of edibles can take several hours, leading some impatient teens to take more — and causing intense and unpredictable highs.