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Fenfluramine was an appetite suppressant which was used to treat obesity. [8] It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. [8] In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome. [7] [38]
Once you consolidate your sleep into a five- or six-hour window, you can start backing up your bedtime, she says. If you had been staying awake until 2 a.m., move it back to 1:30.
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
Fenfluramine was sold as a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [ 12 ] [ 13 ] In 1994, sales of the combination drug Fen-phen ( fenfluramine and phentermine ) increased dramatically, as this combination produced substantial and apparent synergistic effect in promoting weight loss.
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [19]
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Sleep (album) Sleep. (album) Sleep is an eight-and-a-half hour concept album based around the neuroscience of sleep [3] by German-British composer Max Richter. [4][5] It was released on September 4, 2015, accompanied by a one-hour version with variations, From Sleep, [6] later remixed as Sleep Remixes. [7]
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine. It does this by concomitantly inhibiting the serotonin transporter (SERT), norepinephrine ...