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Metformin can help improve your rate of ovulation, increasing your chances of getting pregnant. And metformin has benefits even after you get pregnant. It can reduce your risk of developing...
Does taking metformin increase the chance of birth defects? Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Use of metformin during pregnancy is not expected to increase the chance of having a baby with a birth defect.
All individuals with diabetes and reproductive potential should be informed about the importance of achieving and maintaining as near euglycemia as safely possible prior to conception and throughout pregnancy.
Some people have concerns about using metformin during and after pregnancy because it crosses the placenta. This means that when a pregnant person takes metformin, so does their fetus....
Metformin use during pregnancy may increase insulin sensitivity, thereby decreasing the risk of maternal and fetal complications. 2
In recent years, metformin has gained acceptance as a safe, effective and rational option for reducing insulin resistance in pregnant women with type 2 diabetes, gestational diabetes (GDM) or polycystic ovarian syndrome (PCOS). It may also provide benefit in obese non-diabetic women during pregnancy.
Metformin is well-tolerated during pregnancy and is unlikely to harm a fetus, but there may be risks. Here’s what research says about metformin use in pregnancy.
Metformin has been validated for maternal efficacy and safety, achieving comparable glycemic control with insulin. Additionally, it reduces maternal weight gain and possibly the occurrence of hypertensive disorders.
Although metformin has the potential to counteract gestational insulin resistance (which stands at the core of GDM pathophysiology), there is much uncertainty about its use during pregnancy, so that international guidelines differ in their recommendations.
Metformin for any indication during pregnancy is associated with lower GWG and a modest reduced risk of pre-eclampsia, but increased gastrointestinal side-effects compared to other...