Search results
Results from the WOW.Com Content Network
Hypergastrinemia involves increased levels of gastrin, a hormone that aids digestion. This affects acid levels in your stomach. Hypergastrinemia may be caused by long-term use of antacids or proton pump inhibitors (PPIs), H. pylori infection, certain surgeries and other conditions.
Higher gastrin levels can cause higher levels of gastric acid in your stomach and duodenum. Too much acid can erode the mucous lining in your stomach and duodenum, causing ulcers (peptic ulcer disease). Too much stomach acid can also contribute to chronic acid reflux (GERD).
By far, the two most common causes of high gastrin levels are anti-acid medications you take for reflux or heartburn and a condition called chronic atrophic gastritis. These both can do...
Measuring serum gastrin level is a non-specific measure of hypergastrinemia, and one of the first steps in evaluating patients presenting with symptoms consistent with that disorder. Results may range from mild- to severely elevated gastrin levels based on etiology.
There are several causes of high stomach acid. Examples include H. pylori infection, Zollinger-Ellison syndrome, and rebound effects from medication withdrawal.
Hypergastrinemia: Causes and Treatments. Hypergastrinemia is a medical condition characterized by elevated levels of gastrin, a hormone that stimulates the secretion of gastric acid by the stomach. This condition can lead to various gastrointestinal issues, including gastritis and peptic ulcers, and may indicate underlying health concerns.
The conditions we discuss here are commonly associated with high gastrin levels, but this single symptom is not enough for a diagnosis. Work with your doctor to discover what underlying condition might be causing you hypergastrinemia and to develop an appropriate plan to improve your health.
Here’s some information about gastrin levels from Mayo Clinic: "While elevated gastrin may indicate tumors in your pancreas or duodenum, it also can be caused by other conditions. For example, gastrin may also be elevated if your stomach isn't making acid, or you're taking acid-reducing medications, such as proton pump inhibitors.
Unregulated secretion of gastrin by gastrinomas leads to hyperstimulation and hyperplasia of gastric mucosal parietal cells and ECL cells. Hyperplasia and hyperactivity of these cells result in excessive secretion of gastric acid into the stomach.
Measurement of fasting gastrin has an important role in delineating the various causes of high gastric acid output states. Serum gastrin levels >150 pg/ml are abnormal, and levels > 1000 pg/ml indicate a high probability of ZES.