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A cerebroprotectant (formerly known as a neuroprotectant) is a drug that is intended to protect the brain after the onset of acute ischemic stroke. [1] As stroke is the second largest cause of death worldwide and a leading cause of adult disability, over 150 drugs have been tested in clinical trials to provide cerebroprotection. [2] [3] [4]
A recent paper reports that the use of the drug tenecteplase, not yet approved for stroke treatment in the U.S., may lead to slightly better outcomes after a stroke than the commonly used alteplase.
The most common use is for ischemic stroke. It can either be administered systemically, in the case of acute myocardial infarction , acute ischemic stroke , and most cases of acute massive pulmonary embolism , or administered through an arterial catheter directly to the site of occlusion in the case of peripheral arterial thrombi and thrombi in ...
When applied to protecting the brain from the effects of acute ischemic stroke, neuroprotectants are often called cerebroprotectants. Over 150 drugs have been tested in clinical trials, leading to the regulatory approval of tissue plasminogen activator in several countries, and the approval of edaravone in Japan.
Cerebral infarction, also known as an ischemic stroke, is the pathologic process that results in an area of necrotic tissue in the brain (cerebral infarct). [1] In mid to high income countries, a stroke is the main reason for disability among people and the 2nd cause of death. [2]
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. [5]
For this study, researchers analyzed medical data for more than 7,000 adults who had an ischemic stroke — the most common type of stroke caused by a blood clot in the artery that brings blood to ...
Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. [1] This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. [2] It is a sub-type of stroke along with subarachnoid hemorrhage and intracerebral hemorrhage. [3]
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