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Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [8] body dysmorphic disorder [9] [10] [11] and chronic pain. [7]
Concerns with polypharmacy and elderly groups are reduced medication adherence, increased fall risk, cognitive function impairment, and adverse drug reaction. [11] Almost 75% of clinic visits result in people obtaining a written prescription. [12] [13] More careful prescribing practices could increase medication adherence in elderly people.
Side effects may also be less troublesome if treatment is initiated with low doses and then gradually increased, although this may also delay the beneficial effects. TCAs can behave like class 1A antiarrhythmics , as such, they can theoretically terminate ventricular fibrillation, decrease cardiac contractility and increase collateral blood ...
Approximately 3% of healthy elderly persons living in the community have major depression. Recurrence may be as high as 40%. Suicide rates are nearly twice as high in depressed patients as in the general population. Major depression is more common in medically ill patients who are older than 70 years and hospitalized or institutionalized.
For this observational study, researchers analyzed data from the U.K. Biobank and Whitehall II study of more than 20,000 adults in the U.K. 70 years and older with or without previous ...
[68] [69] The antipsychotic effects of chlorpromazine were discovered in 1952, [70] and imipramine was then developed and studied as an antipsychotic for use in patients with schizophrenia. [ 33 ] [ 71 ] The medication was tested in several hundred patients with psychosis , but showed little effectiveness. [ 72 ]
The U.S. Preventive Services Task Force released a draft recommendation advising against using vitamin D to prevent falls and fractures in people over 60. Pharmacist Katy Dubinsky weighs in.
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