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Neuroplasticity is the process by which neurons adapt to a disturbance over time, and most often occurs in response to repeated exposure to stimuli. [27] Aerobic exercise increases the production of neurotrophic factors [note 1] (e.g., BDNF, IGF-1, VEGF) which mediate improvements in cognitive functions and various forms of memory by promoting blood vessel formation in the brain, adult ...
Post-exertional malaise is a worsening of symptoms after minimal physical or mental activity, [6] and is a cardinal symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). [7] Both PEM and exercise intolerance are common in long COVID. [8] [9] Orthostatic intolerance (OI) occurs in ME/CFS. OI includes exercise intolerance as one ...
Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.
Pacing aims to manage symptoms by avoiding the "boom and bust" cycle that is common among people exceeding their current, limited capacities. This often leads to being forced to stop their activities as a result of pain, fatigue or other symptoms, and then requiring a large amount of rest before being able to resume their activity.
Physical exercise results in numerous health benefits and is an important tool to combat obesity and its co-morbidities, including cardiovascular diseases. Exercise prevents both the onset and development of cardiovascular disease and is an important therapeutic tool to improve outcomes for patients with cardiovascular disease.
Frailty or frailty syndrome refers to a state of health in which older adults gradually lose their bodies' in-built reserves and functioning. This makes them more vulnerable, less able to recover and even apparently minor events (infections, environmental changes) can have drastic impacts on their physical and mental health.
Fatigue is a state of tiredness (which is not sleepiness), exhaustion [1] or loss of energy. [ 2 ] [ 3 ] Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease , organ failure , chronic pain conditions, mood disorders , heart disease , infectious diseases , and post-infectious-disease states ...
Management of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) focuses on symptoms management, as no treatments that address the root cause of the illness are available. [ 1 ] : 29 Pacing, or regulating one's activities to avoid triggering worse symptoms, is the most common management strategy for post-exertional malaise .
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