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The intravenous use of methylphenidate, commonly marketed as Ritalin and widely used as a stimulant drug in the treatment of attention deficit hyperactivity disorder, can lead to emphysematous changes known as Ritalin lung. The mechanism underlying this link is not clearly understood.
Restrictive lung diseases are a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung expansion, [2] resulting in a decreased lung volume, an increased work of breathing, and inadequate ventilation and/or oxygenation. Pulmonary function test demonstrates a decrease in the forced vital capacity.
Other pneumatoses in the lungs are focal (localized) blebs and bullae, pulmonary cysts and cavities. Pneumoperitoneum (or peritoneal emphysema) is air or gas in the abdominal cavity, and is most commonly caused by gastrointestinal perforation, often the result of surgery. Pneumarthrosis, the presence of air in a joint, is rarely a serious sign.
Well-demarcated, nodular lesions ranging 2–5 mm in pulmonary parenchyma. Type II pneumocytes without nuclear atypia lined thickened alveolar septa and proliferated papillary structures. Enlarged cuboidal cells lining mildly thickened alveolar septa. [11] Enlarged cuboidal cells have abundant, eosinophilic cytoplasm and large, round nuclei. [12]
Pulmonary fibrosis is perpetuated by aberrant wound healing, rather than chronic inflammation. [15] It is the main cause of restrictive lung disease that is intrinsic to the lung parenchyma. In contrast, quadriplegia [16] and kyphosis [17] are examples of causes of restrictive lung disease that do not necessarily involve pulmonary fibrosis.
Combined pulmonary fibrosis and emphysema (CPFE), describes a medical syndrome involving both pulmonary fibrosis and emphysema. [1] [2] The combination is most commonly found in male smokers. Pulmonary function tests typically show preserved lung volume with very low transfer factor. [3]
A diver with symptoms of mediastinal emphysema may also have any combination of arterial gas embolism, pneumothorax and subcutaneous or pulmonary interstitial emphysema. Factors which may prevent free escape of the compressed breathing gas include holding the breath or respiratory obstructions such as cysts, mucus plugs, or scar tissue. [10]
An axial CT image showing bullous emphysema of the lungs. There are larger air pockets on the right than left. Bullous emphysema is a condition seen in patients with chronic obstructive pulmonary disease (COPD). The units making up the substructure of the lung (alveoli) become permanently enlarged due to the destruction of their walls.
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