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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
By binding to μ-opioid receptors, loperamide inhibits acetylcholine release and decreases excitation of neurons in the myenteric plexus, which leads to a decrease in peristalsis. [4] Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating ...
It contains loperamide and simethicone. Loperamide is a μ-opioid receptor agonist that works in the intestines. [1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal ...
Vitamin D supplementation for postmenopausal women and older men — given that those populations had normal vitamin D levels, no previous fractures, and no issues with bone density — was found ...
These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). [ 2 ] Mechanisms of peripheral selectivity include physicochemical hydrophilicity and large molecular size, which prevent drug permeation through the lipid bilayer cell membranes of the blood–brain barrier, and efflux out of the brain by ...
"The sensitivity to GI side effects of GLP1s may be more pronounced in women because they already have a longer gut transit time compared to men," says Beverly Tchang, MD, Obesity Medicine Advisor ...
Neuroleptics act primarily on this dopamine system, and older neuroleptics, which have greater affinity for the D2 binding site, are associated with high risk for tardive dyskinesia. [20] The D2 hypersensitivity hypothesis is also supported by evidence of a dose–response relationship , withdrawal effects, studies on D2 agonists and ...
However, later on, the following is stated: Loperamide can be present in breast milk, and is not recommended for breast feeding mothers.. One of the sources may be wrong or wrongly explained in the article. Richard Wolf VI 04:29, 3 March 2018 (UTC) This is not uncommon nor a contradiction.