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  2. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]

  3. Anaprazole - Wikipedia

    en.wikipedia.org/wiki/Anaprazole

    It is classified as a proton pump inhibitor (PPI). [1] It was approved for use in China in 2023. [ 2 ] It is formulated as its sodium salt, anaprazole sodium, in enteric-coated tablets .

  4. Proton-pump inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proton-pump_inhibitor

    In general, proton pump inhibitors are well tolerated, and the incidence of short-term adverse effects is relatively low. The range and occurrence of adverse effects are similar for all of the PPIs, though they have been reported more frequently with omeprazole. This may be due to its longer availability and, hence, clinical experience.

  5. Omeprazole - Wikipedia

    en.wikipedia.org/wiki/Omeprazole

    Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. [9] It can be taken by mouth or by injection into a vein . [ 1 ] [ 10 ] It is also available in the fixed-dose combination medication omeprazole/sodium bicarbonate as Zegerid [ 11 ] [ 12 ] and as Konvomep.

  6. Drugs for acid-related disorders - Wikipedia

    en.wikipedia.org/wiki/Drugs_for_acid-related...

    Proton-pump inhibitors are named using the suffix "-prazole". There is a purported correlation (but no proven causal link) between the use of PPIs and the risk of dementia. [ 6 ] However, this remain controversial as chronic and co-morbid pathology, and resultant polypharmacy (including increased consumption of PPIs), will probably itself also ...

  7. Cimetidine - Wikipedia

    en.wikipedia.org/wiki/Cimetidine

    With the development of proton pump inhibitors, such as omeprazole, approved for the same indications, cimetidine is available as an over-the-counter formulation to prevent heartburn or acid indigestion, along with the other H2-receptor antagonists. [12] Cimetidine was developed in 1971 and came into commercial use in 1977.

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  9. Dexlansoprazole - Wikipedia

    en.wikipedia.org/wiki/Dexlansoprazole

    Effectiveness is similar to other proton pump inhibitors (PPIs). [4] It is taken by mouth. [3] Common side effects include diarrhea, abdominal pain, and nausea. [3] Serious side effects may include osteoporosis, low blood magnesium, Clostridioides difficile infection, anaphylaxis, and pneumonia. [3] Use in pregnancy and breastfeeding is of ...

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