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Bone metastases can cause severe pain, bone fractures, spinal cord compression, hypercalcemia, anemia, spinal instability, decreased mobility, and rapid degradation in the quality of life for patients. [7] [8] Patients have described the pain as a dull ache that grows worse over time, with intermittent periods of sharp, jagged pain. [3]
Cancer pain treatment aims to relieve pain with minimal adverse treatment effects, allowing the person a good quality of life and level of function and a relatively painless death. [27] Though 80–90 percent of cancer pain can be eliminated or well controlled, nearly half of all people with cancer pain in the developed world and more than 80 ...
Treatment for some bone cancers may involve surgery, such as limb amputation, or limb sparing surgery (often in combination with chemotherapy and radiation therapy). Limb sparing surgery , or limb salvage surgery, means the limb is spared from amputation .
Potentially painful cancer treatments include immunotherapy which may produce joint or muscle pain; radiotherapy, which can cause skin reactions, enteritis, fibrosis, myelopathy, bone necrosis, neuropathy or plexopathy; chemotherapy, often associated with mucositis, joint pain, muscle pain, peripheral neuropathy and abdominal pain due to ...
Pain and sensory abnormalities can persist for months or years after treatment completion. Some patients may experience “coasting,” where symptoms intensify after completion of treatment. [3] As such, patients can be cancer-free and still suffer from disabling neuropathy induced by cancer treatment. [3]
Illustration showing the most common site of bone lesions in vertebrae. Bone pain affects almost 70% of people with multiple myeloma and is one of the most common symptoms. [2]: 653 [23] Myeloma bone pain usually involves the spine and ribs and worsens with activity. Persistent, localized pain may indicate a pathological bone fracture.
Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. [6]: 55–59 It is also given for cancers with a high risk of micrometastatic disease. [8]: 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). It can be used when there is little evidence ...
Bone pain originates from both the periosteum and the bone marrow which relay nociceptive signals to the brain creating the sensation of pain. Bone tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated sensory neurons. In combination, they can provide an initial burst of pain, initiated by the faster myelinated ...