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Unregulated PAF signaling can cause pathological inflammation and has been found to be a cause in sepsis, shock, and traumatic injury. PAF can be used as a local signaling molecule and travel over very short distances or it can be circulated throughout the body and act via endocrine. PAF initiates an inflammatory response in allergic reactions. [7]
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. [ 5 ] [ 6 ] It is encoded in the human by the PTAFR gene . The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF).
The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction . 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H 2 O 1-alkyl-sn-glycero-3-phosphocholine + acetate
Pure autonomic failure (PAF) is an uncommon, sporadic neurodegenerative condition marked by a steadily declining autonomic regulation. [3] Bradbury and Eggleston originally described pure autonomic failure in 1925. [4] Patients usually present with orthostatic hypotension or syncope in midlife or later.
The enzyme N-acetylgalactosaminoglycan deacetylase (EC 3.1.1.58) catalyzes the reaction . N-acetyl-D-galactosaminoglycan + H 2 O D-galactosaminoglycan + acetate. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds.
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The US Military refers to the Maritime Militia as the People's Armed Forces Maritime Militia (PAFMM). [3]For reportedly operating in the South China Sea without clear identification, they are sometimes referred to as the "little blue men", a term coined by Andrew S. Erickson of the Naval War College, in reference to Russia's "little green men" during its 2014 annexation of Crimea.
The enzyme 4-nitrophenylphosphatase (EC 3.1.3.41) catalyzes the reaction . 4-nitrophenyl phosphate + H 2 O 4-nitrophenol + phosphate. This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds.