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  2. Fatty acid oxidation inhibitors - Wikipedia

    en.wikipedia.org/.../Fatty_acid_oxidation_inhibitors

    CPT-I inhibitors: etomoxir, oxfenicine, perhexiline CPT-I (carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine. Carnitine biosynthesis inhibitor: mildronate [1] 3-KAT inhibitors: trimetazidine 3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation.

  3. Fatty-acyl-CoA synthase - Wikipedia

    en.wikipedia.org/wiki/Fatty-acyl-CoA_synthase

    Fatty-acyl-CoA synthase, or more commonly known as yeast fatty acid synthase (and not to be confused with long chain fatty acyl-CoA synthetase), is an enzyme complex responsible for fatty acid biosynthesis, and is of Type I Fatty Acid Synthesis (FAS). Yeast fatty acid synthase plays a pivotal role in fatty acid synthesis.

  4. Antiarthritics - Wikipedia

    en.wikipedia.org/wiki/Antiarthritics

    Analgesics or painkillers are defined as medications that help to manage and reduce pain. It is often used in treatments of arthritis to provide relief on the site of injury. Acetaminophen, opioids and counterirritants are common analgesics used in the therapy of arthritis. However, these drugs have no control over inflammation. [25]

  5. Palmitoylethanolamide - Wikipedia

    en.wikipedia.org/wiki/Palmitoylethanolamide

    In 1975, Czech physicians described the results of a clinical trial [clarification needed] looking at joint pain, where the analgesic action of aspirin versus PEA was tested; both drugs were reported to enhance joint movements and decrease pain. [7] In 1970 the drug manufacturer Spofa in Czechoslovakia introduced Impulsin, a tablet dose of PEA ...

  6. Acyl-CoA - Wikipedia

    en.wikipedia.org/wiki/Acyl-CoA

    The latter conversion is mediated by acyl-CoA synthase" acyl-P + HS-CoA → acyl-S-CoA + P i + H + Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. [3] For example, the substrates for medium chain acyl-CoA synthase are 4-11 carbon fatty acids. [4] The enzyme acyl-CoA thioesterase takes of the acyl ...

  7. Coenzyme A - Wikipedia

    en.wikipedia.org/wiki/Coenzyme_A

    Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle.All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate.

  8. Long-chain-fatty-acid—CoA ligase - Wikipedia

    en.wikipedia.org/wiki/Long-chain-fatty-acid—CoA...

    The long chain fatty acyl-CoA ligase (or synthetase) is an enzyme (EC 6.2.1.3) of the ligase family that activates the oxidation of complex fatty acids. [2] Long chain fatty acyl-CoA synthetase catalyzes the formation of fatty acyl-CoA by a two-step process proceeding through an adenylated intermediate. [3]

  9. Acetyl-CoA synthetase - Wikipedia

    en.wikipedia.org/wiki/Acetyl-CoA_synthetase

    Acetyl-CoA synthetase (ACS) or Acetate—CoA ligase is an enzyme (EC 6.2.1.1) involved in metabolism of acetate. It is in the ligase class of enzymes, meaning that it catalyzes the formation of a new chemical bond between two large molecules.

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