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DNA-PK forms a complex that leads to its autophosphorylation, resulting in activation of Artemis. The coding end hairpins are opened by the activity of Artemis. [17] If they are opened at the center, a blunt DNA end will result; however in many cases, the opening is "off-center" and results in extra bases remaining on one strand (an overhang).
Exonucleases remove these unpaired nucleotides and the gaps are filled by DNA synthesis and repair machinery. [1] [3] Exonucleases may also cause shortening of this junction, however this process is still poorly understood. [4] Junctional diversity is liable to cause frame-shift mutations and thus production of non-functional proteins ...
Somatic recombination, as opposed to the genetic recombination that occurs in meiosis, is an alteration of the DNA of a somatic cell that is inherited by its daughter cells. The term is usually reserved for large-scale alterations of DNA such as chromosomal translocations and deletions and not applied to point mutations.
Christoph Cremer (born in Freiburg im Breisgau, Germany) is a German physicist and emeritus [1] at the Ruprecht-Karls-University Heidelberg, former honorary professor at the University of Mainz [2] [3] and was a former group leader at Institute of Molecular Biology (IMB) at the Johannes Gutenberg University of Mainz, Germany, [4] who has successfully overcome the conventional limit of ...
The eukaryotic cell seems to have evolved from a symbiotic community of prokaryotic cells. DNA-bearing organelles like mitochondria and chloroplasts are remnants of ancient symbiotic oxygen-breathing bacteria and cyanobacteria, respectively, where at least part of the rest of the cell may have been derived from an ancestral archaean prokaryote ...
The central and rightmost cell are in interphase, so their DNA is diffuse and the entire nuclei are labelled. The cell on the left is going through mitosis and its chromosomes have condensed. Cell nucleus: A cell's information center, the cell nucleus is the most conspicuous organelle found in a eukaryotic cell.
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
The cell on the left is going through mitosis and its DNA has condensed. In biology , cell theory is a scientific theory first formulated in the mid-nineteenth century, that living organisms are made up of cells , that they are the basic structural/organizational unit of all organisms, and that all cells come from pre-existing cells.