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Intravenous sodium bicarbonate, also known as sodium hydrogen carbonate, is a medication primarily used to treat severe metabolic acidosis. [2] For this purpose it is generally only used when the pH is less than 7.1 and when the underlying cause is either diarrhea , vomiting , or the kidneys . [ 3 ]
A 2004 statement by the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society (for children) uses slightly different cutoffs, where mild DKA is defined by pH 7.20–7.30 (bicarbonate 10–15 mmol/L), moderate DKA by pH 7.1–7.2 (bicarbonate 5–10) and severe DKA by pH<7.1 (bicarbonate below 5).
Sodium bicarbonate 8.4%, 13 mL; Potassium chloride (2 mEq/mL), 13 mL; Lidocaine 1%, 13 mL; Oxygenated whole blood is then added at a four-part crystalloid to one-part whole blood ratio, typically using the Heart-lung machine's circuit as it is delivered to the patient.
In most athletes exercising and sweating for 4–5 hours with a sweat sodium concentration of less than 50 mmol/L, the total sodium lost is less than 10% of total body stores (total stores are approximately 2,500 mmol, or 58 g for a 70-kg person). [41] These losses appear to be well tolerated by most people.
Bicarbonate ions constitute 48% of river water solutes but only 0.14% for seawater. [ 14 ] [ 15 ] Differences like these are due to the varying residence times of seawater solutes; sodium and chloride have very long residence times, while calcium (vital for carbonate formation) tends to precipitate much more quickly. [ 15 ]
10–36 mmol/L potassium (higher than plasma) 1.2–2.8 mmol/L calcium (similar to plasma) 0.08–0.5 mmol/L magnesium; 5–40 mmol/L chloride (lower than plasma) 25 mmol/L bicarbonate (higher than plasma) 1.4–39 mmol/L phosphate; Iodine (mmol/L concentration is usually higher than plasma, but dependent variable according to dietary iodine ...
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