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Norelgestromin is available only as a transdermal contraceptive patch in combination with ethinyl estradiol. [6] The Ortho Evra patch is a 20 cm 2, once-weekly adhesive that contains 6.0 mg norelgestromin and 0.6 mg ethinyl estradiol and delivers 200 μg/day norelgestromin and 35 μg/day ethinyl estradiol.
Norgestimate is available only in combination with the estrogens ethinylestradiol and estradiol. [6] These formulations are for use by mouth and are indicated specifically for hormonal contraception and menopausal hormone therapy. [6] Norgestimate is not available on its own (i.e., as a standalone medication). [6]
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. [7] [8] In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers.
[14] [15] However, a different study concluded that the risk of nonfatal venous thromboembolism for the contraceptive patch is similar to the risk for oral contraceptives containing 35 μg of ethinylestradiol and norgestimate. [16]
Possible weight gain: Some women may experience slight weight gain when using the implant. [24] However, current studies are not conclusive because they do not compare the weight of women using implants with a control group of women not using the implant. The average increase in body weight in studies was less than 5 pounds (2,25 kg) over 2 years.
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Norgestrel is used in combination with ethinylestradiol or quinestrol in combined birth control pills, alone in progestogen-only birth control pills, and in combination with estradiol or conjugated estrogens in menopausal hormone therapy. [7] It has also been used as an emergency contraceptive in the Yuzpe regimen. [16]