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Troponin T (blue) anchors the complex on tropomyosin. Troponin is found in both skeletal muscle and cardiac muscle, but the specific versions of troponin differ between types of muscle. The main difference is that the TnC subunit of troponin in skeletal muscle has four calcium ion-binding sites, whereas in cardiac muscle there are only three.
Test Sensitivity and specificity Approximate peak Description Troponin test: The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is composed of 3 proteins- Troponin C, Cardic troponin I, and Cardiac troponin T. Troponin I especially has a high affinity for myocardial injury.
Troponin I is a biomarker that responds to treatment interventions. Reductions in troponin I levels proved to reduce the risk of future CVD. [23] [24] [25] High sensitive troponin I used as a screening tool to assess a person's cardiovascular risk and has the potential to reduce the growing cost burden of the healthcare system. [26]
The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL. [5] The reference range for the high sensitivity troponin T is a normal < 14 ng/L, borderline of 14-52 ng/L, and elevated of >52 ng/L. [6]
7135 21952 Ensembl ENSG00000159173 ENSMUSG00000026418 UniProt P19237 Q9WUZ5 RefSeq (mRNA) NM_003281 NM_001112702 NM_021467 RefSeq (protein) NP_003272 NP_001106173 NP_067442 Location (UCSC) Chr 1: 201.4 – 201.43 Mb Chr 1: 135.71 – 135.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. It is ...
Cardiac troponin T (low sensitive) 0.1 [7] ng/mL: 99th percentile cutoff: Cardiac troponin I (high sensitive) 0.03 [7] ng/mL 99th percentile cutoff: Cardiac troponin T (high sensitive) Male 0.022 [7] ng/mL 99th percentile cutoff: Female 0.014 [7] ng/mL 99th percentile cutoff: newborn/infants not established more than adults [60] [61]
Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. [ 5 ] [ 6 ] It is a tissue-specific subtype of troponin I , which in turn is a part of the troponin complex . The TNNI3 gene encoding cardiac troponin I (cTnI) is located at 19q13.4 in the human chromosomal genome.
Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. [ 5 ] [ 6 ] Cardiac TnT is the tropomyosin -binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.