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Cocaine is a non-selective, competitive inhibitor of monoamine transporters, sharing a similar mechanism with that of methylphenidate. Cocaine interacts with DAT, SERT, and NET, although the behavioral and reinforcing effects of cocaine depend on its inhibition of DAT and the increase in extracellular dopamine. [1]
This suggests a positive neuromodulatory action of CART on the effects of psychostimulants in rats. [18] CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene is associated with alcoholism. [19] By inhibiting the rewarding effects of cocaine, CART has a potential use in treating cocaine ...
Cocaine is a central nervous system stimulant. [46] Its effects can last from 15 minutes to an hour. The duration of cocaine's effects depends on the amount taken and the route of administration. [47] Cocaine can be in the form of fine white powder and has a bitter taste.
Each neurotransmitter has very specific degradation pathways at regulatory points, which may be targeted by the body's regulatory system or medication. Cocaine blocks a dopamine transporter responsible for the reuptake of dopamine. Without the transporter, dopamine diffuses much more slowly from the synaptic cleft and continues to activate the ...
For example, neuronal body size decreased in response to opiates. [ 8 ] [ 14 ] [ 22 ] [ 34 ] Although the structural changes in the VTA invoked by exposure to an addictive drug generally disappear after a week or two, the target regions of the VTA, including the NAc, may be where the longer-term changes associated with addiction occur during ...
6531 13162 Ensembl ENSG00000142319 ENSG00000276996 ENSMUSG00000021609 UniProt Q01959 Q61327 RefSeq (mRNA) NM_001044 NM_010020 RefSeq (protein) NP_001035 NP_034150 Location (UCSC) Chr 5: 1.39 – 1.45 Mb Chr 13: 73.68 – 73.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded ...
WebMD said this is due to several factors: the types of drugs mixed in the pink cocaine; whether alcohol is involved; how much pink cocaine is taken; and how the body reacts to the drugs.
The structure of the neuron allows chemical information to be received by its dendrites, propagated through the perikaryon (cell body) and down its axon, and eventually passing on to other neurons through its axon terminal. These voltage-gated ion channels allow for rapid depolarization throughout the cell.