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Anti-ulcer agents are medications or supplements used to cure the damage of mucosal layer on organs to prevent the damage from further extending to deeper regions to cause complications. An anti-ulcer medication for treating mouth ulcer is triamcinolone, a corticosteroid. Other anti-ulcer supplements include vitamin B2 and vitamin B12.
A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection. [2] Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion.
Sucralfate is used for the treatment of active duodenal ulcers not related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs), as the mechanism behind these ulcers is due to acid oversecretion. [1] It is not FDA approved for gastric ulcers, but is widely used because of evidence of efficacy. [10]
Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, [1] healing of gastroduodenal ulcers, and treatment of gastritis. [2] It works by enhancing mucosal defense, scavenging free radicals, [3] and temporarily activating genes encoding cyclooxygenase-2.
Sakamoto, C (2004). "The role of mucoprotective drugs in gastric ulcer treatment: with specific reference to their effects on gastritis mucosa". Nippon Rinsho. Japanese Journal of Clinical Medicine. 62 (3): 566–70. PMID 15038105. DRUG PROFILE OF NOVAL ANTIULCER AND MUCOPROTECTIVE DRUG
Misoprostol is a synthetic prostaglandin medication used to prevent and treat stomach and duodenal ulcers, induce labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. [10] [11] It is taken by mouth when used to prevent gastric ulcers in people taking nonsteroidal anti-inflammatory drugs (NSAID). [11]