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A single dose when breastfeeding appears safe. [9] Fosfomycin works by interfering with the production of the bacterial cell wall. [8] Fosfomycin was discovered in 1969 and approved for medical use in the United States in 1996 [globalize] [8] [10] It is on the World Health Organization's List of Essential Medicines. [11]
[9] Meta-analyses conclude that fluoroquinolones pose little or no additional risk to children compared to other antibiotic classes. [ 10 ] [ 11 ] [ 12 ] Fluoroquinolone use in children may be appropriate when the infection is caused by multidrug-resistant bacteria , or when alternative treatment options require parenteral administration and ...
Cefuroxime is active against many bacteria including susceptible strains of Staphylococci and Streptococci, as well as a range of gram negative organisms. [11] As with the other cephalosporins, it is susceptible to beta-lactamase, although as a second-generation variety, it is less so.
Cefuroxime axetil, sold under the brand name Ceftin among others, is a second generation oral cephalosporin antibiotic.. It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally. [2]
The first sulfonamide and the first systemically active antibacterial drug, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany, [9] [10] [11] for which Domagk received the 1939 Nobel Prize in Physiology or Medicine. [139]
[10] [12] The British National Formulary previously issued blanket warnings of 10% cross-reactivity, but, since the September 2008 edition, suggests, in the absence of suitable alternatives, oral cefixime or cefuroxime and injectable cefotaxime, ceftazidime, and ceftriaxone can be used with caution, but the use of cefaclor, cefadroxil ...
Lepeule et al. determined that in mice, the ideal pharmacodynamic target of fT>MIC=33%, where MIC is the minimum inhibitory concentration, was obtained with 200 mg/kg every four hours. [46] The fT>MIC (%) was increased by 11% when the administration frequency was increased from every four hours to every three hours. [ 46 ]
A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in excess of 25 mg/wk. Antivirals , more specifically, lamivudine (increased plasma concentrations of lamivudine), zalcitabine (increased plasma concentrations of zalcitabine) and zidovudine (increased risk of haematological reactions)