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Peptidoglycan or murein is a unique large macromolecule, a polysaccharide, consisting of sugars and amino acids that forms a mesh-like layer (sacculus) that surrounds the bacterial cytoplasmic membrane. [1]
Peptidoglycan, also called murein, is a polymer that makes up the cell wall of most bacteria. It is made up of sugars and amino acids, and when many molecules of peptidoglycan joined together, they form an orderly crystal lattice structure.
Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discovery of novel antibiotic targets, and its role in infection.
Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discovery of novel antibiotic targets, and its role in infection. …
The peptidoglycan cell wall surrounds the cytoplasmic membrane and prevents osmotic lysis. Peptidoglycan is composed of interlocking chains of building blocks called peptidoglycan monomers.
Peptidoglycan is the outermost cell wall layer of gram-positive bacteria. In gram-negative bacteria, additional layers are present outside this rigid layer, called lipopolysaccharide. The peptidoglycan layer is much thicker in gram-positive than in gram-negative bacteria.
Peptidoglycan is the major structural polymer in most bacterial cell walls and consists of glycan chains of repeating N-acetylglucosamine and N-acetylmuramic acid residues cross-linked via peptide side chains. Peptidoglycan hydrolases are produced by many bacteria, bacteriophages and eukaryotes.
In this Review we present our current understanding of how peptidoglycan synthases are regulated by multiple and specific interactions with cell morphogenesis proteins that are linked to a...
Peptidoglycan is the predominant stress‐bearing structure in the cell envelope of most bacteria, and also a potent stimulator of the eukaryotic immune system. Obligate intracellular bacteria replicate exclusively within the interior of living cells, an osmotically protected niche.
Peptidoglycan is an important structural component of bacterial cell walls, and mammalian cells express a number of distinct pattern-recognition receptors that detect peptidoglycan...