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The Dog Aging Project is an open science initiative. The investigators have committed to releasing all anonymized research data to the public domain. The longitudinal study portion of the Dog Aging Project bears some similarity to the Golden Retriever Lifetime Study of the Morris Animal Foundation although with much larger phenotypic diversity.
Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency, such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or more than 80% decrease in clearance thereof. [18]
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
In one study, [3] [27] 1534 juvenile patients (age 6 months to 16 years) treated with levofloxacin as part of three efficacy trials were followed up to assess all musculoskeletal events occurring up to 12 months post-treatment. At 12 months follow-up the cumulative incidence of musculoskeletal adverse events was 3.4%, compared to 1.8% among 893 ...
The maximum tolerable dose (MTD) information is necessary to be able to design such groups and therefore dose-ranging studies are usually designed after the availability of MTD information. [1] The main goal of a dose-ranging study is to estimate the response vs. dose given, so as to analyze the efficacy and safety of the drug.
Explore multiple discount card options: Numerous websites and organizations offer free prescription discount cards. Try using several different cards to see which one provides the best price for ...
Enrofloxacin, sold under the brand name Baytril, among others, is a fluoroquinolone antibiotic used for the treatment of animals. [1] It is a bactericidal agent. [1]The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure.
A dose–response curve is a coordinate graph relating the magnitude of a dose (stimulus) to the response of a biological system. A number of effects (or endpoints) can be studied. The applied dose is generally plotted on the X axis and the response is plotted on the Y axis. In some cases, it is the logarithm of the dose that is plotted on the ...
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