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For many years, it was believed that the axon hillock was the usual site of initiation of action potentials—the trigger zone. It is now thought that the earliest site of action potential initiation is at the axonal initial segment: just between the peak of the axon hillock and the initial (unmyelinated) segment of the axon. [3]
These channels help transmit the signals generated by the dendrites. Emerging out from the soma is the axon hillock. This region is characterized by having a very high concentration of voltage-activated sodium channels. In general, it is considered to be the spike initiation zone for action potentials, [18] i.e. the trigger zone. Multiple ...
In neuroscience and neurology, a trigger zone is an area in the body, or of a cell, in which a specific type of stimulation triggers a specific type of response.. The term was first used in this context around 1914 by Hugh T. Patrick, who was writing about trigeminal neuralgia, a condition in which pain fibers in the trigeminal nerve become hypersensitive. [1]
Created Date: 8/30/2012 4:52:52 PM
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A type Ia sensory fiber, or a primary afferent fiber, is a type of afferent nerve fiber. [1] It is the sensory fiber of a stretch receptor called the muscle spindle found in muscles, which constantly monitors the rate at which a muscle stretch changes. The information carried by type Ia fibers contributes to the sense of proprioception.
The part of the axon where it emerges from the soma is called the axon hillock. Besides being an anatomical structure, the axon hillock also has the greatest density of voltage-dependent sodium channels. This makes it the most easily excited part of the neuron and the spike initiation zone for the axon.
Therefore, the postsynaptic potential attenuates by the time it reaches the neuron cell body. The neuron cell body acts as a computer by integrating (adding or summing up) the incoming potentials. The net potential is then transmitted to the axon hillock, where the action potential is initiated. Another factor that should be considered is the ...